Download PDF Hoff and E. Lubbers and J. Appelton H. No month. Association of Official Analytical Chemists, In: Official Methods of Analysis, 13th ed. Horowitz W. Association of Official Analytical Chemists. Washington, D. Aieta and J. Aieta, E. Hong D. Columnbia Dept. This is a Continuation of application Ser. I claim: 1. A two-part sterilizing system comprising: a a first part comprising sodium chlorite solution; and b a second part comprising an organic acid and a corrosion inhibitor, said organic acid comprises citric acid, sorbic acid, and boric acid, and said corrosion inhibitor comprising a copper and brass corrosion inhibitor, a steel and aluminum corrosion inhibitor, and a buffering agent; wherein said first part and said second part, when combined, provide a sterilizing composition having a pH of about 5.
A two-part sterilizing system according to claim 1, wherein the copper and brass corrosion inhibitor is a triazole or benzotriazole present in a weight percent of 0. The two-part sterilizing system according to claim 1, wherein the steel and aluminum corrosion inhibitor is selected from the group consisting of phosphates, molybdates, and nitrates, and is present in a weight percent of from 0. The two-part sterilizing system according to claim 1, further comprising a steel and ferric corrosion inhibitor comprising sodium nitrate.
The two-part sterilizing system according to claim 1, further comprising a sequestering agent. The two-part sterilizing system according to claim 1, further comprising a wetting agent, a defoamer, or a combination thereof.
The two-part sterilizing system according to claim 1, wherein said buffering agent comprises trisodium phosphate. A sterilizing composition comprising: a sodium chlorite solution; b an organic acid comprising citric acid, sorbic acid, and boric acid; c a buffering agent comprising trisodium phosphate; d a corrosion inhibitor comprising a copper and brass corrosion inhibitor, and a steel and aluminum corrosion inhibitor.
The composition according to claim 8, wherein said composition has a pH of about 5. A method for sterilizing medical instruments, said method comprising: a preparing a sterilizing composition by combining a first part comprising sodium chlorite solution, and a second part comprising an organic acid, a corrosion inhibitor, and a buffering agent, wherein the organic acid comprises citric acid, sorbic acid, and boric acid; b introducing a medical instrument into the sterilizing composition to effect sterilization of the medical instrument.
The method for sterilizing medical instruments according to claim 10, further comprising a step of: a adjusting the pH of the sterilizing composition to about 5. EXAMPLE 1 Effect of Activating Acid The possible contribution of acid used to activate base sodium chlorite convert the stabilised chlorine dioxide into free chlorine dioxide towards the biocidal activity of chlorine dioxide has been investigated.
Corrosion Test Procedure The test involves imposing on the test specimen a steadily increasing aggressive potential and observing the resulting anodic current. Results Uninhibited Solution Uninhibited electrolyte was harmless to the stainless steels but was aggressive towards brass and both pure aluminium and its two alloys.
Inhibited Solution Very good inhibition was expected and found on the stainless steels. Conclusion It was concluded that the solution with inhibitor provided more than adequate protection of the metal parts from the biocide even when used for extended immersion periods, four times longer than recommended.
Next Patent Method of improving Corrosion inhibitor and sealable thread protector end cap for tubular goods. Office size instrument sterilization system. Method for preparing stabilized aqueous chlorine dioxide solution. Powdered anti-microbial composition. Anti-microbial composition. Biocidal composition and method for disinfecting articles. Stabilized activated oxygen and pharmaceutical compositions containing said stabilized activated oxygen.
Germ-killing composition and method. Germ-killing materials. Preparation and method for treating burns. The present invention is deemed to be applicable to all agar media and gels prepared in Petri dishes or similarly constructed containers such as plastic containers manufactured for the purpose of containing an agar or gel medium for the purpose of growing microorganisms or demonstrating a microbial reaction such as agar immuno-diffusion.
The achieving of an improved process for preserving plated media and gels and improved packaging for such media and gels thus becomes the primary object of the invention. Other objects will appear as the description proceeds. The invention is based on storing microbiological media and gels in a conventional, disposable, sterile Petri dish or similar container having optical clarity and a loose fitting cover and typically formed of polystyrene.
An air, liquid and light impervious paper-plastic film-foil pouch in which the Petri dish containing the media is stored is first treated with a sterilizing agent. The Petri dish or similar container containing the medium or gel is then inserted into the pouch. The pouch is next evacuated to remove oxygen from both the pouch and the Petri dish.
Next, an inert gas is introduced and the vacuum is relieved. The pouch is next heat sealed while remaining under partial vacuum. The chamber vacuum is then relieved which collapses the pouch around the product to produce the packaged product of the invention.
Making reference to the drawings, the microbiological medium or gel to be preserved is preferably placed in a disposable, sterile, Petri dish 10 or similar container, typically formed of polystyrene, having optical clarity and sufficient strength to withstand the vacuum sealing process of the invention without breakage.
The Petri dish 10 or similar container receives the microbiological medium or gel 12 to be preserved and in the case of the Petri dish comprises the typical round bottom dish 14 in which the medium 12 is stored and a loose fitting top cover An air, liquid, and light impervious pouch 20 is employed and which is typically formed of a plastic-paper-foil laminate with three sealed sides 21, 22 and 23 and an initially unsealed, open end 24 through which the Petri dish 10 or similar container to be stored is inserted.
It is an important feature of the experiment that the applied potential should change slowly typically 0. The electrolytes correspond to working biocidal solutions with or without inhibitor. Uninhibited electrolyte was harmless to the stainless steels but was aggressive towards brass and both pure aluminium and its two alloys. In practical use there would be a risk of contamination of stainless steel components with corrosion products notably copper from brass.
This could lead to harmful galvanic effects. Aluminium and its two alloys did not withstand the solution without inhibitors. It is unlikely that the test pieces would experience conditions in the field as aggressive as those which have produced failures in the laboratory, unless severely contaminated or held for unreasonably long periods in used biocide.
Very good inhibition was expected and found on the stainless steels. There was a notable improvement in performance of brass in these electrolytes and this promises well for the behaviour of multi-metal articles. Excellent inhibition of aluminium was obtained.
The duration of the corrosion tests was longer than the recommended sterilizing time; immersions of 2 hours at the open circuit potentials were harmless to the test pieces. Potentials of metals and potential differences between metal components are unlikely to produce a corrosive effect greater than that corresponding to It was concluded that the solution with inhibitor provided more than adequate protection of the metal parts from the biocide even when used for extended immersion periods, four times longer than recommended.
The acid activator was added to the sodium chlorite solution to produce a sterilant system. The system was used to sterilize a number of test medical instruments, for example endoscopes. After repeated treatment, no corrosion was observed. In a comparative test, a non-inhibited system showed that pitting was developing on metal parts.
I claim: 1. A method for sterilizing medical instruments, said method comprising: a preparing a sterilizing composition by combining: i a first part comprising sodium chlorite solution; and. A method for sterilizing medical instruments according to claim 1, wherein said buffering agent comprising trisodium phosphate. A method for sterilizing medical instruments according to claim 1, wherein the copper and brass corrosion inhibitor is a triazole or benzotriazole present in a weight percent of 0.
A method for sterilizing medical instruments according to claim 1, wherein the steel and aluminum corrosion inhibitor is selected from the group consisting of phosphates, molybdates and nitrates and is present in a weight percent of from 0.
A method for sterilizing medical instruments according to claim 1, wherein said sterilizing composition further comprises a steel and ferric corrosion inhibitor comprising sodium nitrate. A method for sterilizing medical instruments according to claim 1, wherein said sterilizing composition further comprises a sequestering agent.
A method for sterilizing medical instruments according to claim 1, wherein said sterilizing composition further comprises a wetting agent, a defoamer, or a combination thereof. A method for sterilizing medical instruments, said method comprising: a preparing a sterilizing composition by combining a first part comprising sodium chlorite solution, and a second part comprising an organic acid, a corrosion inhibitor, and a buffering agent, said organic acid comprising citric acid, sorbic acid and boric acid;.
A method for sterilizing medical instruments according to claim 8, wherein said endoscope comprises a glass fiber endoscope. A method for sterilizing medical instruments according to claim 8, further comprising a step of: a adjusting the pH of the sterilizing composition to about 5. A method for sterilizing medical instruments according to claim 8, wherein said buffering agent comprises trisodium phosphate.
A method for sterilizing medical instruments according to claim 8, wherein said corrosion inhibitor comprises a triazole or benzotriazole. A method for sterilizing medical instruments according to claim 8, wherein said corrosion inhibitor is selected from the group consisting of phosphates, molybdates and nitrates. A method for sterilizing medical instruments according to claim 8, wherein said corrosion inhibitor comprises sodium nitrate. A method for sterilizing medical instruments according to claim 8, wherein said sterilizing composition comprises a sequestering agent.
A method for sterilizing medical instruments according to claim 8, wherein said sterilizing composition comprises a wetting agent, a defoamer, or a combination thereof. USA true USA en. Permeation method and apparatus for preparing fluids containing high purity chlorine dioxide.
USB2 en. Stabilized chlorine dioxide solutions containing a chloride and processes of making and using same. Stabilized activated oxygen and pharmaceutical compositions containing said stabilized activated oxygen. GBD0 en. Aieta, E. Appelton H. Association of Official Analytical Chemists, In: Official Methods of Analysis, 13th ed. A sterilant must provide specified levels of micro-organism kills or inactivations as measured by reductions of coliforms, heterotrophic plate count organisms and Legionella bacteria.
Disinfection is currently defined by the Environmental Protection Agency to mean Disinfection is expressed as a CT value i. At the CT values necessary for chlorine dioxide to inactivate According to the present invention, an end solution of ppm C is preferred.
This provides a greater sterilizing effect than other systems known in the art. Chloride dioxide may be liberated from the sodium chlorite. Combinations of suitable acids. The corrosion means that expensive instruments have a shortened lifetime.
A number of corrosion inhibitors are available and are well-known. However, if an oxidizing agent, for example chlorine dioxide, is to be used as the sterilizing agent, various problems must be overcome in selecting suitable inhibitors. The main problem is that the inhibitors must be effective in powerful oxidizing solutions where chloride ions are present.
Furthermore, the inhibitors must be stable under long-term storage in acidic conditions, and must not react together to form deposits or harmful reaction products. The inhibitors should not present a health hazard, either when left in trace quantities on the sterilized instruments or prior to use. The cleaning environment also produces special problems. The oxygen liberating agent is acidic.
Because a number of different metals may be in the sterilizing tank at the same time, galvanic corrosion may be initiated. There is. In accordance with the present invention, a new and improved anti-microbial composition is provided which overcomes the over problems.
An anti-microbial solution is provided which comprises an oxidizing anti-microbial agent, a copper and brass corrosion inhibitor and buffering agent, a wetting agent and sequestering agent. The copper and brass corrosion inhibitor is selected from the class consisting essentially of triazoles, azoles, benzoates, and five membered ring compounds.
Triazoles, particularly benzotriazole and tolytriazole are preferred as being stable in the presence of strong oxidizing compounds. Benzotriazole is most preferred as it also helps to prevent galvanic corrosion in mixed metal systems.
Mercaptobenzathiozal might also be utilized but may be destabilized by strong oxidizers. They might be present at 0. The aluminium and steel corrosion inhibitor and the buffering agent may be selected from the class consisting essentially of chromates, dichromates, borates, nitrates, phosphates, molybdates, vanadates and tungsdates. More specifically to the preferred embodiment, phosphates are preferred of inhibiting steel corrosion and buffering the solution.
Molybdates are preferred for inhibiting aluminium corrosion and nitrates, particularly sodium nitrate, for inhibiting steel and ferric corrosion. The anti-corrosive buffering compounds may include a mixture of phosphate in sufficient volume to produce a final concentration of 1. Phosphates may also be effective in the range of 0. Optionally, chromates, dichromates, tungstates, vanadates, other borates, and combinations thereof may be substituted in appropriate concentrations to inhibit steel corrosions and aluminium corrosion.
Amines are often used as corrosion inhibitors. However, amine derivatives were rejected because of unpredictable film forming properties. In hard water, calcium and magnesium salts can precipitate and coat the instruments being sterilized. A sequestering agent appropriate to prevent precipitation, such as sodium hexametaphosphate, may be provided; if deior. However, to ensure universal applicability with any water that might be utilized, the presence of a sequestering agent is preferred.
It has been found that sodium citrate and trisodium phosphate also act as sequestering agents.
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